Article
p53 gene mutation in recurrent superficial bladder cancer.
The Journal of urology - 1 May 1995
Yoshimura I, Kudoh J, Saito S, Tazaki H, Shimizu N
Abstract excerpt
Surgical specimens from 30 patients with transitional cell carcinoma of the bladder were examined for the presence of mutation of the p53 tumor suppressor gene using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis. All of the specimens were superficial, low grade cancer, and 10 patients had recurrences during an observation period of 24 months following the initial surgical...
Topics
- Carcinoma, Transitional Cell
- Genes, p53
- Humans
- Mutation
- Neoplasm Recurrence, Local
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Prognosis
- Urinary Bladder Neoplasms
