Article
Dynamics of chromosomal aberrations in male mice of various strains during aging.
Bulletin of experimental biology and medicine - 1 May 2001
Rozenfel'd S V, Togo E F, Mikheev V S, Popovich I G, Zabezhinskii M A, Anisimov V N
Abstract excerpt
We studied the incidence of chromosome aberrations in bone marrow cells and primary spermatocytes in various mouse strains. Experiments were performed on SAMP mice (accelerated aging), control SAMR mice, and long-living CBA and SHR mice. Experiments revealed a positive correlation between the age and the incidence of mutations in their somatic cells and gametes.
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