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Article

Aging of Male Germ Line Stem Cells in Mice1

22 Sept 2005

Abstract excerpt

In the present study, we investigated the effect of aging on spermatogonial stem cells (SSCs) and on the testicular somatic environment in ROSA26 mice. First, we examined testis weights at 2 mo, 6 mo, 1 yr, and 2 yr of age. At 1 and 2 yr, bilateral atrophied testes were observed in 50% and 75% of the mice, respectively; the rest of the mice had testis weights similar to those of young mice. Next, we evaluated the...

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PMID: 16177220
DOI: 10.1095/biolreprod.105.045591

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