Article
Maternal effects of the scid mutation on radiation-induced transgenerational instability in mice.
Oncogene - 12 Jul 2007
Hatch T, Derijck A A H A, Black P D, van der Heijden G W, de Boer P, Dubrova Y E
Abstract excerpt
The results of a number of recent studies show that mutation rates in the offspring of irradiated parents are substantially elevated, however, the effect of parental genotype on transgenerational instability remains poorly understood. Here, we have analysed the mutation frequency at an expanded simple tandem repeat (ESTR) locus in the germline and bone marrow of the first-generation male offspring of control and...
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