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Article

Hippocampal SPARC regulates depression-related behavior.

Genes, brain, and behavior - 1 Nov 2012

Campolongo M, Benedetti L, Podhajcer O L, Pitossi F, Depino A M

Abstract excerpt

SPARC (secreted protein acidic and rich in cysteine) is a matricellular protein highly expressed during development, reorganization and tissue repair. In the central nervous system, glial cells express SPARC during development and in neurogenic regions of the adult brain. Astrocytes control the glutamate receptor levels in the developing hippocampus through SPARC secretion. To further characterize the role of...

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Identifiers

PMID: 22950524
DOI: 10.1111/j.1601-183X.2012.00848.x

Genes

SPARC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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