Article
Drug resistance in patients experiencing early virological failure under a triple combination including indinavir.
AIDS (London, England) - 7 Sept 2001
Gallego O, de Mendoza C, Pérez-Elías M J, Guardiola J M, Pedreira J, Dalmau D, Gónzalez J, Moreno A, Arribas J R, Rubio A, García-Arata I, Leal M, Domingo P, Soriano V
Abstract excerpt
OBJECTIVE: To assess the pattern of drug resistance mutations selected in HIV-1-infected patients failing a first line triple combination therapy including indinavir. PATIENTS AND METHODS: Plasma samples from 87 patients collected at the time of the first virological rebound (> 50 HIV-RNA copies/ml) were examined for the presence of drug-resistant genotypes. RESULTS: The mean level of plasma viraemia at rebound...
Topics
- Adult
- Anti-HIV Agents
- Drug Resistance, Viral
- Drug Therapy, Combination
- Female
- HIV Infections
- HIV Protease
- HIV Protease Inhibitors
- HIV Reverse Transcriptase
- HIV-1