Article
High levels of drug-resistant human immunodeficiency virus variants in patients exhibiting increasing CD4+ T cell counts despite virologic failure of protease inhibitor-containing antiretroviral combination therapy.
The Journal of infectious diseases - 1 May 2000
Bélec L, Piketty C, Si-Mohamed A, Goujon C, Hallouin M C, Cotigny S, Weiss L, Kazatchkine M D
Abstract excerpt
The genotypic mutations associated with indinavir resistance were analyzed in 27 patients who exhibited sustained CD4+ T cell responses to highly active antiretroviral therapy (HAART), despite virologic failure of treatment. After 12 months of HAART, 1 or 2 primary resistance mutations had occurred in 18 (66%) of the patients, and secondary mutations had accumulated in 22 (88%) of the patients. The number and...
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