Article
Overcoming resistance: virologic response to a salvage regimen with the combination of ritonavir plus indinavir.
HIV clinical trials - 1 Jan 2000
Casado Jose L, Moreno Ana, Martí-Belda Paloma, Sabido Raquel, Pinheiro Sofía, Bermudez Elena, Antela Antonio, Dronda Fernando, Perez-Elías María J, Moreno Santiago
Abstract excerpt
PURPOSE: To explore the possibility of overcoming resistance to protease inhibitors (PIs) and to determine the resistance cutoff values that continue to predict treatment failure with a dual PI regimen. METHOD: We performed a prospective study of 53 patients who had failed in several PIs and who were included in a ritonavir (RTV) plus indinavir (IDV) salvage regimen. Median HIV RNA level decrease was evaluated...
Topics
- Adult
- Drug Resistance, Viral
- Drug Therapy, Combination
- Female
- Genotype
- HIV
- HIV Infections
- HIV Protease
- HIV Protease Inhibitors
- Humans
- Indinavir
- Male
- Mutation
- RNA, Viral