Article
Duplicate mitf genes in zebrafish: complementary expression and conservation of melanogenic potential.
Developmental biology - 15 Sept 2001
Lister J A, Close J, Raible D W
Abstract excerpt
Mutations in the zebrafish nacre/mitfa gene, expressed in all embryonic melanogenic cells, perturb only neural crest melanocytes, suggesting redundancy of mitfa with another gene in the zebrafish retinal pigment epithelium (RPE). Here, we describe a second zebrafish mitf gene, mitfb, which may fulfill this role. The proteins encoded by the two zebrafish mitf genes appear homologous to distinct isoforms generated...
Topics
- 3T3 Cells
- Alleles
- Amino Acid Sequence
- Animals
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Cells, Cultured
- Cloning, Molecular
- DNA-Binding Proteins
- Exons
- In Situ Hybridization
- Luciferases