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Article

Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment.

Trends in pharmacological sciences - 1 Aug 1999

Ingelman-Sundberg M, Oscarson M, McLellan R A

Abstract excerpt

Approximately 40% of human P450-dependent drug metabolism is carried out by polymorphic enzymes, which can cause abolished, quantitatively or qualitatively altered or enhanced drug metabolism. The latter situation is due to stable duplication, multiduplication or amplification of active genes, most likely in response to dietary components that have resulted in a selection of alleles with multiple non-inducible...

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Identifiers

PMID: 10431214
DOI: 10.1016/s0165-6147(99)01363-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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