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Article

Mutational signatures and mutagenic impacts associated with betel quid chewing in oral squamous cell carcinoma.

Human genetics - 1 Dec 2019

Su Shih-Chi, Chang Lun-Ching, Lin Chiao-Wen, Chen Mu-Kuan, Yu Chun-Ping, Chung Wen-Hung, Yang Shun-Fa

Abstract excerpt

Betel quid (BQ) chewing is a prevailing risk for oral squamous cell carcinoma (OSCC) in Southeast Asia. Yet, the detailed mechanisms by which BQ chewing damages the genome are still not fully understood. Through exome sequencing of tumor-normal pairs from 196 male patients with OSCC, including 95 habitual BQ chewers and 101 non-BQ users, we conducted a quantitative survey of mutational signatures and genomic...

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Identifiers

PMID: 31679052
DOI: 10.1007/s00439-019-02083-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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