TLR4 D299G polymorphism modulates cytokine expression in ulcerative colitis.

doi:10.1097/MCG.0b013e31828a6e93

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Article

TLR4 D299G polymorphism modulates cytokine expression in ulcerative colitis.

Journal of clinical gastroenterology - 1 Oct 2013

Meena Naresh K, Verma Ravi, Verma Nirmal, Ahuja Vineet, Paul Jaishree

Abstract excerpt

BACKGROUND: Toll-like receptor 4 (TLR4) is a key cell surface receptor which recognizes lipopolysaccharide that leads to activation of innate immune system. Association of single nucleotide polymorphisms (SNPs) in TLR4 gene with the inflammatory bowel disease is influenced by ethnicity of the study population. GOAL: To study association of SNPs in TLR4 gene in inflammatory bowel disease patients and to explore...

Topics

Adolescent
Adult
Analysis of Variance
Case-Control Studies
Colitis, Ulcerative
Crohn Disease
Cytokines
Female
Genotype
Humans
India
Inflammation Mediators

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Polymorphism, Single Nucleotide

RNA, Messenger

Toll-Like Receptor 4

Source

Open in PubMed

Identifiers

PMID: 23470644
DOI: 10.1097/MCG.0b013e31828a6e93

Genes

TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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