Article
Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome.
Cytogenetics and cell genetics - 1 Jan 2001
Akeson E C, Lambert J P, Narayanswami S, Gardiner K, Bechtel L J, Davisson M T
Abstract excerpt
Fluorescent in situ hybridization (FISH) -- using mouse chromosome paints, probes for the mouse major centromeric satellite DNA, and probes for genes on chromosomes (Chr) 16 and 17 -- was employed to locate the breakpoint in a translocation used to produce a mouse model for Down syndrome. The Ts65Dn trisomy is derived from the reciprocal translocation T(16;17)65Dn. The Ts65Dn mouse carries a marker chromosome...
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