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Article

Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2011

Reinholdt Laura G, Ding Yueming, Gilbert Griffith J, Gilbert Griffith T, Czechanski Anne, Solzak Jeffrey P, Roper Randall J, Johnson Mark T, Donahue Leah Rae, Lutz Cathleen, Davisson Muriel T

Abstract excerpt

Ts65Dn is a mouse model of Down syndrome: a syndrome that results from chromosome (Chr) 21 trisomy and is associated with congenital defects, cognitive impairment, and ultimately Alzheimer's disease. Ts65Dn mice have segmental trisomy for distal mouse Chr 16, a region sharing conserved synteny with human Chr 21. As a result, this strain harbors three copies of over half of the human Chr 21 orthologs. The trisomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21953412
DOI: 10.1007/s00335-011-9357-z
PMCID: PMC3505986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn.PMID 21953412Read ↗

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