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Article

Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes.

Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2005

Vacík Tomás, Ort Michael, Gregorová Sona, Strnad Petr, Blatny Radek, Conte Nathalie, Bradley Allan, Bures Jan, Forejt Jirí

Abstract excerpt

Triplication of whole autosomes or large autosomal segments is detrimental to the development of a mammalian embryo. The trisomy of human chromosome (Chr) 21, known as Down's syndrome, is regularly associated with mental retardation and a variable set of other developmental anomalies. Several mouse models of Down's syndrome, triplicating 33-104 genes of Chr16, were designed in an attempt to analyze the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15755806
DOI: 10.1073/pnas.0500802102
PMCID: PMC552979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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