Article
Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development.
Genomics - 1 Oct 2001
Hurle B, Lane K, Kenney J, Tarantino L M, Bucan M, Brownstein B H, Ornitz D M
Abstract excerpt
The tilted (tlt) mouse carries a recessive mutation causing vestibular dysfunction. The defect in tlt homozygous mice is limited to the utricle and saccule of the inner ear, which completely lack otoconia. Genetic mapping of tlt placed it in a region orthologous with human 4p16.3-p15 that contains two loci, DFNA6 and DFNA14, responsible for autosomal dominant, nonsyndromic hereditary hearing impairment. To...
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