Article
Characterization of the DNA-binding property of Smad5.
Biochemical and biophysical research communications - 7 Sept 2001
Li W, Chen F, Nagarajan R P, Liu X, Chen Y
Abstract excerpt
Activation of TGF-beta superfamily receptors leads to phosphorylation of Smad proteins which function as transcription factors to regulate gene expression. Previous studies have indicated that Smad5, together with Smad1 and Smad8, participates in signaling downstream of BMP receptors. To characterize the DNA-binding characteristics of Smad5, we used the GST-Smad5 N-terminal fusion protein to select for random...
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