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Article

The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-A potential therapeutic target

7 Feb 2015

Abstract excerpt

Members of the transforming growth factor-β (TGF-β) superfamily transduce signals via SMAD proteins. SMAD2 and SMAD3 mediate TGF-β signaling, whereas SMAD1, SMAD5, and SMAD8/9 transduce bone morphogenetic protein (BMP) signals. We would like to identify the function of BMP/SMAD5 signaling in serous ovarian cancer. The protein levels of total SMAD5 and phosphorylated SMAD5 (pSMAD5) were examined by...

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PMID: 25663289
DOI: 10.1002/mc.22283

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