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Article

Investigating the structure and dynamics of the PIK3CA wild-type and H1047R oncogenic mutant.

PLoS computational biology - 1 Oct 2014

Gkeka Paraskevi, Evangelidis Thomas, Pavlaki Maria, Lazani Vasiliki, Christoforidis Savvas, Agianian Bogos, Cournia Zoe

Abstract excerpt

The PIK3CA gene is one of the most frequently mutated oncogenes in human cancers. It encodes p110α, the catalytic subunit of phosphatidylinositol 3-kinase alpha (PI3Kα), which activates signaling cascades leading to cell proliferation, survival, and cell growth. The most frequent mutation in PIK3CA is H1047R, which results in enzymatic overactivation. Understanding how the H1047R mutation causes the enhanced...

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PMID: 25340423
DOI: 10.1371/journal.pcbi.1003895
PMCID: PMC4207468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Investigating the structure and dynamics of the PIK3CA wild-type and H1047R oncogenic mutant.PMID 25340423Read ↗

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