Article
New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice.
Physiological genomics - 28 Aug 2001
Ivandic B T, Utz H F, Kaczmarek P M, Aherrahrou Z, Axtner S B, Klepsch C, Lusis A J, Katus H A
Abstract excerpt
Dystrophic cardiac calcinosis (DCC) occurs among certain inbred strains of mice and involves necrosis and subsequent calcification as response of myocardial tissue to injury. Using a complete linkage map approach, we investigated the genetics of DCC in an F(2) intercross of resistant C57BL/6J and susceptible C3H/HeJ inbred strains and identified previously a major predisposing quantitative trait locus (QTL),...
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