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Article

Predicting affinity- and specificity-enhancing mutations at protein-protein interfaces.

Biochemical Society transactions - 1 Oct 2013

Sharabi Oz, Shirian Jason, Shifman Julia M

Abstract excerpt

Manipulations of PPIs (protein-protein interactions) are important for many biological applications such as synthetic biology and drug design. Combinatorial methods have been traditionally used for such manipulations, failing, however, to explain the effects achieved. We developed a computational method for prediction of changes in free energy of binding due to mutation that bring about deeper understanding of...

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Identifiers

PMID: 24059503
DOI: 10.1042/BST20130121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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