Functional single nucleotide polymorphism-1026C/A of inducible nitric oxide synthase gene with increased YY1-binding affinity is associated with hypertension in a Chinese Han population.

Abstract excerpt

BACKGROUND: In our previous linkage analysis of Chinese hypertensive families, a hypertension susceptibility region on chromosome 17 was located at D17S1878, which encompasses the inducible nitric oxide synthase (iNOS) gene. OBJECTIVE: The aim of this study was to investigate the association between variant in the human iNOS gene and susceptibility to hypertension in Chinese Han. METHODS AND RESULTS: We detected...

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