Article
Detection of p53 gene mutations by nonisotopic RNase cleavage assay as a predictor of poor prognosis in colorectal cancers.
Digestive diseases and sciences - 1 Oct 2003
Haseba Masatoshi, Hidaka Shigekazu, Tsuji Takashi, Yano Hiroshi, Komatsu Hideaki, Sawai Terumitu, Yasutake Toru, Nakagoe Tohru, Tagawa Yutaka, Ayabe Hiroyoshi
Abstract excerpt
The present study was undertaken to evaluate p53 gene mutation as a prognostic factor in patients with colorectal cancer. Nonisotopic RNase cleavage assay (NIRCA), recently used for detecting gene mutations, was employed to detect p53 gene mutations in this study. In 15 samples of colorectal tumors, NIRCA was confirmed to be simple, accurate, and thus useful for clinical use, compared with polymerase chain...
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