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Article

Are genetic polymorphisms in the renin-angiotensin-aldosterone system associated with essential hypertension? Evidence from genome-wide association studies.

Journal of human hypertension - 1 Nov 2017

Ji L-D, Li J-Y, Yao B-B, Cai X-B, Shen Q-J, Xu J

Abstract excerpt

In candidate gene era, dozens of single-nucleotide polymorphisms (SNPs) within renin-angiotensin-aldosterone system (RAAS) have been reported to be significantly associated with hypertension. However, the unbiased genome-wide association studies (GWAS) rarely identified the SNPs within RAAS were associated with hypertension or blood pressure (BP) traits. In order to figure out whether genetic polymorphisms of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28425437
DOI: 10.1038/jhh.2017.29

Genes

ACE
ACE2
AGT
AGTR1
AGTR2
AGTRAP
ATP6AP2
CLCN6
CYP11B2
HSD11B2
MAS1
MTHFR
NPPA
NPPB
NR3C2
REN
RENBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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