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Article

Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors.

The Journal of biological chemistry - 19 Oct 2001

Yang W, Hong Y H, Shen X Q, Frankowski C, Camp H S, Leff T

Abstract excerpt

AMP-activated protein kinase (AMP-kinase) modulates many metabolic processes in response to fluctuations in cellular energy status. Although most of its known targets are metabolic enzymes, it has been proposed that AMP-kinase might also regulate gene expression. Here we demonstrate that the transcriptional coactivator p300 is a substrate of AMP-kinase. Phosphorylation of p300 at serine 89 by AMP-kinase...

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Identifiers

PMID: 11518699
DOI: 10.1074/jbc.C100316200

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GATA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors.PMID 11518699Read ↗

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E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivatorsSemantic proximity Read ↗

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