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Article

Characterization of CCAAT/enhancer-binding protein alpha as a cyclic AMP-responsive nuclear regulator.

The Journal of biological chemistry - 12 Jun 1998

Roesler W J, Park E A, McFie P J

Abstract excerpt

The alpha isoform of CCAAT/enhancer-binding protein (C/EBPalpha) is a transcription factor that regulates expression of genes linked to adipose differentiation and hepatic nutrient metabolism. Recently, our laboratory has characterized a role for C/EBPalpha in mediating hormonal responsiveness. For example, the cAMP responsiveness of the phosphoenolpyruvate carboxykinase gene promoter in liver requires synergism...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9614100
DOI: 10.1074/jbc.273.24.14950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Characterization of CCAAT/enhancer-binding protein alpha as a cyclic AMP-responsive nuclear regulator.PMID 9614100Read ↗

CCAAT/enhancer binding protein alpha (C/EBPalpha) in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBPalpha is associated with serum levels of triglycerides.Semantic proximity Read ↗

CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation.Semantic proximity Read ↗

The Pleiotropic Face of CREB Family Transcription FactorsSemantic proximity Read ↗

p300 Coactivates the Adipogenic Transcription Factor CCAAT/Enhancer-binding Protein αSemantic proximity Read ↗

Role of the CCAAT Enhancer Binding Proteins (C/EBPs) in Adipocyte DifferentiationSemantic proximity Read ↗

Cooperative mechanism of transcriptional activation by a cyclic AMP-response element modulator alpha mutant containing a motif for constitutive binding to CREB-binding protein.Semantic proximity Read ↗

Temporal recruitment of CCAAT/enhancer-binding proteins to early and late adipogenic promoters in vivoSemantic proximity Read ↗

Characteristics of the cAMP response unit.Semantic proximity Read ↗

Activation of Extracellular Signal-Regulated Kinases and CREB/ATF-1 Mediate the Expression of CCAAT/Enhancer Binding Proteins β and -δ in PreadipocytesSemantic proximity Read ↗

Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation.Semantic proximity Read ↗

Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha.Semantic proximity Read ↗

Signal-dependent control of gluconeogenic key enzyme genes through coactivator-associated arginine methyltransferase 1.Semantic proximity Read ↗

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