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Article

Contribution of the second transmembrane helix of the secretin receptor to the positioning of secretin.

FEBS letters - 13 Mar 1998

Di Paolo E, De Neef P, Moguilevsky N, Petry H, Bollen A, Waelbroeck M, Robberecht P

Abstract excerpt

The secretin amino-terminal residues are essential for high affinity binding to its cognate receptor and for its biological activity. Mutation of the [Asp3] residue of secretin to [Asn3] decreased the ligand's affinity for the rat wild-type receptor 100-300-fold. Receptor mutations in the transme...

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Identifiers

PMID: 9539152
DOI: 10.1016/s0014-5793(98)00175-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9539152-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Contribution of the second transmembrane helix of the secretin receptor to the positioning of secretin.PMID 9539152Read ↗

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Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping.Semantic proximity Read ↗

Molecular approximation between residue 10 of secretin and its receptor demonstrated by photoaffinity labeling.Semantic proximity Read ↗

Insights into the structure and molecular basis of ligand docking to the G protein-coupled secretin receptor using charge-modified amino-terminal agonist probes.Semantic proximity Read ↗

Spatial approximation between two residues in the mid-region of secretin and the amino terminus of its receptor. Incorporation of seven sets of such constraints into a three-dimensional model of the agonist-bound secretin receptor.Semantic proximity Read ↗

Impact of secretin receptor homo-dimerization on natural ligand binding.Semantic proximity Read ↗

Differential determinants for coupling of distinct G proteins with the class B secretin receptor.Semantic proximity Read ↗

Asn229 in the third helix of VPAC1 receptor is essential for receptor activation but not for receptor phosphorylation and internalization: comparison with Asn216 in VPAC2 receptor.Semantic proximity Read ↗

Secretin receptor as a target in gastrointestinal cancer: expression analysis and ligand developmentSemantic proximity Read ↗

Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor.Semantic proximity Read ↗

A surface-exposed region of G(salpha) in which substitutions decrease receptor-mediated activation and increase receptor affinity.Semantic proximity Read ↗

Paired cysteine mutagenesis to establish the pattern of disulfide bonds in the functional intact secretin receptor.Semantic proximity Read ↗

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