Modeling linkage disequilibrium between a polymorphic marker locus and a locus affecting complex dichotomous traits in natural populations.

doi:10.1093/genetics/158.4.1785

Back to search

Article

Modeling linkage disequilibrium between a polymorphic marker locus and a locus affecting complex dichotomous traits in natural populations.

Genetics - 1 Aug 2001

Luo Z W, Wu C I

Abstract excerpt

Linkage disequilibrium is an important topic in evolutionary and population genetics. An issue yet to be settled is the theory required to extend the linkage disequilibrium analysis to complex traits. In this study, we present theoretical analysis and methods for detecting or estimating linkage d...

Topics

Alleles
Evolution, Molecular
Genetic Variation
Humans
Likelihood Functions
Linkage Disequilibrium
Models, Genetic
Monte Carlo Method
Polymorphism, Genetic
Quantitative Trait, Heritable
Regression Analysis

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.