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Estimating disequilibrium coefficients.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Vens Maren, Ziegler Andreas

Abstract excerpt

Gametic phase disequilibrium (GPD) is the nonrandom association of alleles within gametes. Linkage disequilibrium (LD) describes the special case of deviation from independence between alleles at two linked genetic loci. Estimation of allelic LD requires knowledge of haplotypes. Genotype-based LD measures dispense with the haplotype estimation step and avoid bias in LD estimation. In this chapter, the most...

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PMID: 22307696
DOI: 10.1007/978-1-61779-555-8_7

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