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Article

Roles of phosphoinositides and of Spo14p (phospholipase D)-generated phosphatidic acid during yeast sporulation.

Molecular biology of the cell - 1 Jan 2004

Rudge Simon A, Sciorra Vicki A, Iwamoto Michelle, Zhou Chun, Strahl Thomas, Morris Andrew J, Thorner Jeremy, Engebrecht JoAnne

Abstract excerpt

During yeast sporulation, internal membrane synthesis ensures that each haploid nucleus is packaged into a spore. Prospore membrane formation requires Spo14p, a phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]-stimulated phospholipase D (PLD), which hydrolyzes phosphatidylcholine (PtdCho) to phosphatidic acid (PtdOH) and choline. We found that both meiosis and spore formation also require the...

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Identifiers

PMID: 14528019
DOI: 10.1091/mbc.e03-04-0245
PMCID: PMC307541

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Roles of phosphoinositides and of Spo14p (phospholipase D)-generated phosphatidic acid during yeast sporulation.PMID 14528019Read ↗

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