Article

SSTR2 as an anatomical imaging marker and a safety switch to monitor and manage CAR T cell toxicity

2022-08-19

Abstract excerpt

The ability to image adoptively transferred T cells in the body and to eliminate them to avoid toxicity will be vital for chimeric antigen receptor (CAR) T cell therapy, particularly against solid tumors with higher risk of off-tumor toxicity. Previously, we have demonstrated the utility of somatostatin receptor 2 (SSTR2) for CAR T cell imaging, illustrating the expansion and contraction of CAR T cells in tumor as...

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Literature Corpus work: 397110c4-e359-5c9b-adbf-2b474f15a68c
DOI: 10.21203/rs.3.rs-1962438/v1

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