Article
The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect.
Protein science : a publication of the Protein Society - 1 Jan 1998
Xu J, Baase W A, Baldwin E, Matthews B W
Abstract excerpt
To further examine the structural and thermodynamic basis of hydrophobic stabilization in proteins, all of the bulky non-polar residues that are buried or largely buried within the core of T4 lysozyme were substituted with alanine. In 25 cases, including eight reported previously, it was possible...
Topics
- Alanine
- Bacteriophage T4
- Crystallography, X-Ray
- Models, Molecular
- Muramidase
- Mutation
- Protein Engineering
- Protein Folding
- Thermodynamics