Article
SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus.
Biochemical and biophysical research communications - 24 Aug 2001
Imoto I, Pimkhaokham A, Fukuda Y, Yang Z Q, Shimada Y, Nomura N, Hirai H, Imamura M, Inazawa J
Abstract excerpt
Amplification of the 3q26 region appears to occur frequently among esophageal squamous cell carcinomas (ESCs). We examined ESC cell lines for amplification and expression levels of four genes in this region: SNO and EVI1, which encode proteins antagonizing transforming growth factor-beta signaling, and two other putative target genes, TERC and PIK3CA. Amplification of SNO was accompanied by significant increases...
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