Article
Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2001
Wagner C A, Ott M, Klingel K, Beck S, Melzig J, Friedrich B, Wild K N, Bröer S, Moschen I, Albers A, Waldegger S, Tümmler B, Egan M E, Geibel J P, Kandolf R, Lang F
Abstract excerpt
Cystic fibrosis (CF) is characterized by impaired Cl(-) secretion and increased Na(+) reabsorption in several tissues including respiratory epithelium. Many CFTR mutations have been identified over the past years. However, only a poor correlation between the genotype and lung phenotype was found suggesting additional factors influencing the phenotype and course of the disease. The serine/threonine kinase SGK1 has...
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