Article
High affinity very late antigen-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM-1 in shear flow.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1999
Chen C, Mobley J L, Dwir O, Shimron F, Grabovsky V, Lobb R R, Shimizu Y, Alon R
Abstract excerpt
The very late Ag-4 (VLA-4) integrin supports both rolling and firm adhesion of leukocytes on VCAM-1 under shear flow. The molecular basis for the unique ability of a single adhesion molecule to mediate these versatile adhesive processes was investigated. VLA-4 occurs in multiple activation states, with different affinities to ligand. In this study we tested how these states regulate VLA-4 adhesiveness under shear...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.