Article
High affinity very late antigen-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM-1 in shear flow.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1999
Chen C, Mobley J L, Dwir O, Shimron F, Grabovsky V, Lobb R R, Shimizu Y, Alon R
Abstract excerpt
The very late Ag-4 (VLA-4) integrin supports both rolling and firm adhesion of leukocytes on VCAM-1 under shear flow. The molecular basis for the unique ability of a single adhesion molecule to mediate these versatile adhesive processes was investigated. VLA-4 occurs in multiple activation states...
Topics
- Cell Adhesion
- Cell Movement
- Fibronectins
- Humans
- Integrin alpha4beta1
- Integrins
- Interphase
- Jurkat Cells
- Lymphocyte Activation
- Microscopy, Immunoelectron
- Mutation
- Receptors, Lymphocyte Homing
- Receptors, Very Late Antigen
- Rheology
- T-Lymphocyte Subsets