Article
Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant.
The Journal of clinical investigation - 1 Nov 2005
Ward Michael E, Toporsian Mourad, Scott Jeremy A, Teoh Hwee, Govindaraju Vasanthi, Quan Adrian, Wener Avraham D, Wang Guilin, Bevan Siân C, Newton Derek C, Marsden Philip A
Abstract excerpt
We tested the hypothesis that induction of neuronal NO synthase (nNOS) impairs vascular smooth muscle contractility after hypoxia. nNOS protein was increased in aorta, mesenteric arterioles, pulmonary arteries, brain, and diaphragm from rats exposed to 8% O2 for 48 hours and in human aortic SMCs after hypoxic incubation (1% O2). Ca-dependent NO synthase activity was increased in endothelium-denuded aortic...
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