Article
Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes.
Diabetologia - 1 Jul 2001
Matsubara A, Wasson J C, Donelan S S, Welling C M, Glaser B, Permutt M A
Abstract excerpt
AIMS/HYPOTHESIS: AKT1, a serine/threonine protein kinase, is an important downstream target of the insulin-signalling pathway, with both anti-apoptotic and peripheral metabolic effects. Because impaired insulin signalling is a major hallmark of Type II (non-insulin-dependent) diabetes mellitus, we considered whether the AKT1 gene could be a candidate gene involved in susceptibility of this condition. To test this...
Topics
- Base Sequence
- Cloning, Molecular
- DNA Primers
- Diabetes Mellitus, Type 2
- Exons
- Genetic Predisposition to Disease
- Genomic Library
- Humans
- Insulin
- Introns
- Jews