AKT1 polymorphisms are associated with risk for metabolic syndrome.

doi:10.1007/s00439-010-0910-8

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Article

AKT1 polymorphisms are associated with risk for metabolic syndrome.

Human genetics - 1 Feb 2011

Devaney Joseph M, Gordish-Dressman Heather, Harmon Brennan T, Bradbury Margaret K, Devaney Stephanie A, Harris Tamara B, Thompson Paul D, Clarkson Priscilla M, Price Thomas B, Angelopoulos Theodore J, Gordon Paul M, Moyna Niall M, Pesca Linda S, VIsich Paul S, Zoeller Robert F, Seip Richard L, Seo Jinwook, Kim Bo Hyoung, Tosi Laura L, Garcia Melissa, Li Rongling, Zmuda Joseph M, Delmonico Matthew J, Lindsay Robert S, Howard Barbara V, Kraus William E, Hoffman Eric P

Abstract excerpt

Converging lines of evidence suggest that AKT1 is a major mediator of the responses to insulin,insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. We hypothesized that AKT1 variants may play a role in the endophenotypes that makeup metabolic syndrome. We studied a 12-kb region including the ﬁrst exon of the AKT1 gene for...

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Identifiers

PMID: 21061022
DOI: 10.1007/s00439-010-0910-8
PMCID: PMC3020305

Genes

AKT1
IGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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