Article
The EWS protein is dispensable for Ewing tumor growth.
Cancer research - 15 Aug 2001
Kovar H, Jug G, Hattinger C, Spahn L, Aryee D N, Ambros P F, Zoubek A, Gadner H
Abstract excerpt
EWS encodes a ubiquitously expressed RNA binding protein with largely unknown function. In Ewing sarcoma family tumors (EFT), one allele is rearranged with an ETS gene. This is the first description of an EFT with a complete EWS deficiency in the presence of two copies of a rearranged chromosome 22 carrying an interstitial EWS-FLI1 translocation. Absence of EWS protein suggested that it is dispensable for EFT...
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