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Article

BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcoma.

PloS one - 1 Jan 2013

Wiles Elizabeth T, Lui-Sargent Bianca, Bell Russell, Lessnick Stephen L

Abstract excerpt

The EWS/FLI translocation product is the causative oncogene in Ewing sarcoma and acts as an aberrant transcription factor. EWS/FLI dysregulates gene expression during tumorigenesis by abnormally activating or repressing genes. The expression levels of thousands of genes are affected in Ewing sarcoma, however, it is unknown which of these genes contribute to the transformed phenotype. Here we characterize BCL11B...

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Share to Oncogene Proteins, Fusion
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Protein c-fli-1

Share to RNA-Binding Protein EWS

Share to Sarcoma, Ewing

Share to Sequence Analysis, RNA

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Source

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Identifiers

PMID: 23527175
DOI: 10.1371/journal.pone.0059369
PMCID: PMC3601955

Genes

SPRY1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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