Article
Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer.
Genes, chromosomes & cancer - 1 Dec 1999
Izatt L, Greenman J, Hodgson S, Ellis D, Watts S, Scott G, Jacobs C, Liebmann R, Zvelebil M J, Mathew C, Solomon E
Abstract excerpt
Epidemiological studies have shown an increased risk of breast cancer in obligate ataxia telangiectasia (A-T) heterozygotes. We analyzed 100 samples from young breast cancer patients for mutations in ataxia-telangiectasia mutated (ATM), the gene responsible for the autosomal recessive condition,...
Topics
- Adult
- Age of Onset
- Aged
- Alleles
- Amino Acid Sequence
- Ataxia Telangiectasia
- Breast Neoplasms
- Breast Neoplasms, Male
- Chromosome Aberrations
- DNA Mutational Analysis
- DNA, Neoplasm
- Exons
- Female
- Germ-Line Mutation
- Humans