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Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer.

Genes, chromosomes & cancer - 1 Dec 1999

Izatt L, Greenman J, Hodgson S, Ellis D, Watts S, Scott G, Jacobs C, Liebmann R, Zvelebil M J, Mathew C, Solomon E

Abstract excerpt

Epidemiological studies have shown an increased risk of breast cancer in obligate ataxia telangiectasia (A-T) heterozygotes. We analyzed 100 samples from young breast cancer patients for mutations in ataxia-telangiectasia mutated (ATM), the gene responsible for the autosomal recessive condition, A-T, to determine whether A-T heterozygosity predisposes such individuals to develop breast cancer. These patients were...

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Identifiers

PMID: 10534763

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer.PMID 10534763Read ↗

Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history.Semantic proximity Read ↗

Rare variants in the ATM gene and risk of breast cancer.Semantic proximity Read ↗

Spectrum of ATM gene mutations in a hospital-based series of unselected breast cancer patients.Semantic proximity Read ↗

ATM mutations in cancer families.Semantic proximity Read ↗

Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer.Semantic proximity Read ↗

Ataxia-telangiectasia gene (ATM) mutation heterozygosity in breast cancer: a narrative review.Semantic proximity Read ↗

The ATM gene and breast cancer: is it really a risk factor?Semantic proximity Read ↗

Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer.Semantic proximity Read ↗

Cancer risks and mortality in heterozygous ATM mutation carriers.Semantic proximity Read ↗

Heterozygous ATM mutations do not contribute to early onset of breast cancerSemantic proximity Read ↗

ATM germline mutations in women with familial breast cancer and a relative with haematological malignancy.Semantic proximity Read ↗

ATM germline mutations in Spanish early-onset breast cancer patients negative for BRCA1/BRCA2 mutations.Semantic proximity Read ↗

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