Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Four PSM/SH2-B Alternative Splice Variants and Their Differential Roles in Mitogenesis

1 Nov 2001

Abstract excerpt

An SH2 domain originally termed SH2-B had been identified as a direct cellular binding target of a number of mostly mitogenic receptors. The complete cellular protein, termed PSM, and respective sequence variants share additional Pro-rich and PH regions, as well as similarities with APS and Lnk. A role of these mediators has been implicated in signaling pathways found downstream of growth hormone receptor and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 protein interactions
Share to Cytokine Signaling Pathways and Interactions
Share to Protein Kinase Regulation and GTPase Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11502739
DOI: 10.1074/jbc.m104191200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Four PSM/SH2-B Alternative Splice Variants and Their Differential Roles in MitogenesisPMID 11502739Read ↗

RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis.Semantic proximity Read ↗

Functional Characterization of Obesity-Associated Variants Involving the α and β Isoforms of Human SH2B1Semantic proximity Read ↗

Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation.Semantic proximity Read ↗

Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activitySemantic proximity Read ↗

Srsf3 mediates alternative RNA splicing downstream of PDGFRα signaling in the facial mesenchyme.Semantic proximity Read ↗

Murine SHP-1 splice variants with altered Src homology 2 (SH2) domains. Implications for the SH2-mediated intramolecular regulation of SHP-1.Semantic proximity Read ↗

Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state.Semantic proximity Read ↗

Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.Semantic proximity Read ↗

Differential signaling and immediate-early gene activation by four splice variants of the human pituitary adenylate cyclase-activating polypeptide receptor (hPACAP-R).Semantic proximity Read ↗

Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptor.Semantic proximity Read ↗

Grb10 and Grb14: enigmatic regulators of insulin action--and more?Semantic proximity Read ↗

Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.