Article
Specific binding of 8-oxoguanine-containing RNA to polynucleotide phosphorylase protein.
Biochemistry - 21 Aug 2001
Hayakawa H, Kuwano M, Sekiguchi M
Abstract excerpt
8-Oxoguanine, an oxidized form of guanine, has the potential to pair with both cytosine and adenine, and thus, the persistence of this base in messenger RNA would cause translational errors. To prevent such an outcome, organisms probably have a mechanism for recognizing RNA molecules carrying 8-oxoguanine and prevent them from entering into the cellular translational machinery. We now report that the Escherichia...
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