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Article

A mutation in polynucleotide phosphorylase from Escherichia coli impairing RNA binding and degradosome stability.

Nucleic acids research - 1 Jan 2004

Regonesi Maria Elena, Briani Federica, Ghetta Andrea, Zangrossi Sandro, Ghisotti Daniela, Tortora Paolo, Dehò Gianni

Abstract excerpt

Polynucleotide phosphorylase (PNPase), a 3' to 5' exonuclease encoded by pnp, plays a key role in Escherichia coli RNA decay. The enzyme, made of three identical 711 amino acid subunits, may also be assembled in the RNA degradosome, a heteromultimeric complex involved in RNA degradation. PNPase a...

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Share to Amino Acid Substitution
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Share to Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Escherichia coli Proteins

Share to Gene Expression Regulation, Bacterial

Share to Polyribonucleotide Nucleotidyltransferase

Share to RNA, Bacterial

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Identifiers

PMID: 14963263
DOI: 10.1093/nar/gkh268
PMCID: PMC373403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14963263-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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