Article
A Naturally Occurring Deletion in FliE from Salmonella enterica Serovar Dublin Results in an Aflagellate Phenotype and Defective Proinflammatory Properties.
Infection and immunity - 1 Jan 2018
Sasías Sebastián, Martínez-Sanguiné Adriana, Betancor Laura, Martínez Arací, D'Alessandro Bruno, Iriarte Andrés, Chabalgoity José A, Yim Lucía
Abstract excerpt
Salmonella enterica serovar Dublin is adapted to cattle but is able to infect humans with high invasiveness. An acute inflammatory response at the intestine helps to prevent Salmonella dissemination to systemic sites. Flagella contribute to this response by providing motility and FliC-mediated signaling through pattern recognition receptors. In a previous work, we reported a high frequency (11 out of 25) of S...
Topics
- Amino Acid Sequence
- Amino Acids
- Animals
- Bacterial Proteins
- Basal Bodies
- Base Sequence
- Cattle
- Female
- Flagella
- Genes, Duplicate
- Humans
- Inflammation
- Mice
- Mice, Inbred C57BL