Article
Analysis of the contribution of Salmonella pathogenicity islands 1 and 2 to enteric disease progression using a novel bovine ileal loop model and a murine model of infectious enterocolitis.
Infection and immunity - 1 Nov 2005
Coombes Brian K, Coburn Bryan A, Potter Andrew A, Gomis Susantha, Mirakhur Kuldip, Li Yuling, Finlay B Brett
Abstract excerpt
We have developed a novel ileal loop model for use in calves to analyze the contribution of Salmonella enterica serovar Typhimurium type III secretion systems to disease processes in vivo. Our model involves constructing ileal loops with end-to-end anastamoses to restore the patency of the small intestine, thereby allowing experimental animals to convalesce following surgery for the desired number of days. This...
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