Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclin D1 and p21 in ulcerative colitis-related inflammation and epithelial neoplasia: a study of aberrant expression and underlying mechanisms.

Human pathology - 1 Jun 2003

Wong Newton A C S, Mayer Nicholas J, Anderson Catriona E, McKenzie Honora C, Morris Robert G, Diebold Joachim, Mayr Doris, Brock Ian W, Royds Janice A, Gilmour Hugh M, Harrison David J

Abstract excerpt

It is unclear whether and how cyclin D1 and/or p21(WAF1/CIP1) dysregulation contribute to ulcerative colitis (UC)-related inflammation and colorectal carcinogenesis. Cases of quiescent UC (QUC; n = 15), active UC (AUC; n = 23), UC-related dysplasia (n = 35) and UC-related colorectal adenocarcinomas (CRCs; n = 11) were studied with cyclin D1 and p21(WAF1/CIP1) immunohistochemistry. The CRCs were also studied with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Cell Division

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colitis, Ulcerative

Share to Cyclin D1

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Cyclins

Share to DNA, Neoplasm

Share to Down-Regulation

Source

Identifiers

PMID: 12827612
DOI: 10.1016/s0046-8177(03)00125-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclin D1 and p21 in ulcerative colitis-related inflammation and epithelial neoplasia: a study of aberrant expression and underlying mechanisms.PMID 12827612Read ↗

A case of adenocarcinoma of the small intestine in a Japanese patient with Crohn disease: a report with immunohistochemical and oncogenic analyses.Semantic proximity Read ↗

WNT-pathway activation in IBD-associated colorectal carcinogenesis: potential biomarkers for colonic surveillance.Semantic proximity Read ↗

Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21 <sup>WAF1/CIP1</sup> expression and correlates with patient survivalSemantic proximity Read ↗

Ulcerative Colitis–Associated Colorectal Cancer Arises in a Field of Short Telomeres, Senescence, and InflammationSemantic proximity Read ↗

p53 Expression as a Diagnostic Biomarker in Ulcerative Colitis-Associated Cancer.Semantic proximity Read ↗

Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesisSemantic proximity Read ↗

p21WAF1/CIP1 expression in colorectal carcinoma correlates with advanced disease stage and p53 mutations.Semantic proximity Read ↗

Analysis of key cell‐cycle checkpoint proteins in colorectal tumoursSemantic proximity Read ↗

A unique basal pattern of p53 expression in ulcerative colitis is associated with mutation in the p53 gene.Semantic proximity Read ↗

Differential Regulation of D-Type Cyclins in the Mouse IntestineSemantic proximity Read ↗

p53 protein expression in ulcerative colitis-associated colorectal dysplasia and carcinomaSemantic proximity Read ↗

Nondysplastic Ulcerative Colitis Has High Levels of the Homologous Recombination Repair Protein NUCKS1 and Low Levels of the DNA Damage Marker Gamma-H2AXSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.