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Article

Osmotic stress-mediated activation of RET kinases involves intracellular disulfide-bonded dimer formation.

Antioxidants & redox signaling - 1 Jun 2001

Takeda K, Kato M, Wu J, Iwashita T, Suzuki H, Takahashi M, Nakashima I

Abstract excerpt

We showed that osmotic stress induces activation of c-RET and second-set activation of constitutively activated RET-MEN2B. A few percentage of RET proteins normally formed disulfide-bonded dimers in the cell, and osmotic stress promoted formation of these dimers. The disulfide-bonded dimers displayed higher levels of autophosphorylation and catalytic activity per molecule than did monomers. Osmotic stress also...

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Source

Identifiers

PMID: 11491658
DOI: 10.1089/15230860152409103

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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