Article
Mechanism of Ret activation by a mutation at aspartic acid 631 identified in sporadic pheochromocytoma.
Biochemical and biophysical research communications - 24 Feb 1999
Asai N, Iwashita T, Murakami H, Takanari H, Ohmori K, Ichihara M, Takahashi M
Abstract excerpt
Mutations at aspartic acid 631 in Ret were reported in sporadic pheochromocytoma and medullary thyroid carcinoma. We replaced this aspartic acid with four other amino acids including tyrosine, glycine, asparagine, and alanine and investigated the transforming activity of these mutant cDNAs. Among them, RET cDNA with a mutation of aspartic acid to tyrosine (D631Y) that was reported in sporadic pheochromocytoma...
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