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Article

The genetics and epigenetics of autoimmune diseases.

Journal of autoimmunity - 1 Aug 2009

Hewagama Anura, Richardson Bruce

Abstract excerpt

Self tolerance loss is fundamental to autoimmunity. While understanding of immune regulation is expanding rapidly, the mechanisms causing loss of tolerance in most autoimmune diseases remain elusive. Autoimmunity is believed to develop when genetically predisposed individuals encounter environmental agents that trigger the disease. Recent advances in the genetic and environmental contributions to autoimmunity...

Topics

Animals
Autoimmune Diseases
Autoimmunity
Chromosomes, Human, X
Environmental Exposure
Epigenesis, Genetic
Female
Gene Expression Regulation
Genetic Predisposition to Disease
Humans
Self Tolerance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

X Chromosome Inactivation

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Open in PubMed Open full text

Identifiers

PMID: 19349147
DOI: 10.1016/j.jaut.2009.03.007
PMCID: PMC2819418

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